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Therapy: Corticosteroid Therapy

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Total 18777 results found since Jan 2013.

CXCR4 Antagonist Reduced the Incidence of Acute Rejection and Controlled Cardiac Allograft Vasculopathy in a Swine Heart Transplant Model Receiving a Mycophenolate-based Immunosuppressive Regimen
Conclusions The augmentation of conventional MMF plus corticosteroids with a CXCR4 antagonist is potentially effective in improving outcomes after heart transplantation in minipigs. Future studies are warranted into optimizing the therapeutic regimens for humans.
Source: Transplantation - November 22, 2018 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research

Typical gene expression profile of pseudorabies virus reactivation from latency in swine trigeminal ganglion
In this study, PRV-free piglets were infected with PRV. Viral shedding in nasal and ocular swabs demonstrated that PRV infection entered the latent period. The anti-PRV antibody was detected by enzyme-linked immunosorbent assay and the serum neutralization test, which suggested that the PRV could establish latent infection in the presence of humoral immunity. Immunohistochemistry and viral genome detection of TG neurons suggested that PRV was reactivated from latency. Viral gene expressions of IE180, EP0, VP16, and LLT-intron were readily detected at 3-h post-DEX treatment, but gB, a γ1 gene, was not detectable. The diffe...
Source: Journal of NeuroVirology - July 14, 2020 Category: Neurology Source Type: research

Health economic analyses of psoriasis management: a systematic literature search
The objective was to identify health economic evaluations of psoriasis treatments that have been published to date. Of particular interest were the mostly used analysis and outcome parameters, the compared treatments, and the question, if available health economic studies may be used to perform a meta-analysis of qualitative findings. A systematic literature search using PubMed Medline, Ovid Medline, and Cochrane Library was performed for articles, published and available until mid of January 2016. Among the key words were the terms “psoriasis” and “cost-effectiveness”. The search resulted in 318 articles without d...
Source: Archives of Dermatological Research - July 18, 2016 Category: Dermatology Source Type: research

Do animal models of brain tumors replicate human peritumoral edema? a systematic literature search
ConclusionNo animal model currently exists that enable the investigation of novel candidates for the treatment of peritumoral brain edema. With current interest in alternative treatments for peritumoral brain edema, there is an unmet need for clinically relevant animal models.
Source: Journal of Neuro-Oncology - February 9, 2023 Category: Cancer & Oncology Source Type: research

What Is the Right Dose of Systemic Corticosteroids for Intensive Care Unit Patients with Chronic Obstructive Pulmonary Disease Exacerbations?. A Question in Search of a Definitive Answer.
PMID: 24787061 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - May 1, 2014 Category: Respiratory Medicine Authors: Abroug F, Krishnan JA Tags: Am J Respir Crit Care Med Source Type: research

Glenohumeral Corticosteroid Injections in Adhesive Capsulitis: A Systematic Search and Review
To assess the literature on outcomes of corticosteroid injections for adhesive capsulitis, and, in particular, image-guided corticosteroid injections.
Source: PM and R - July 1, 2014 Category: Rehabilitation Authors: Amos Song, Laurence D. Higgins, Joel Newman, Nitin B. Jain Tags: Analytical Review: Systematic Search Source Type: research

Analysis of patient-reported symptoms with respect to TCS usage: A self-identified cohort of patients with RSS/TSA/TSW
Background: Topical corticosteroids (TCS) have been the mainstay of treatment for inflammatory dermatoses and are felt to be safe when used appropriately. In response to increased reports about red skin syndrome (RSS) and topical steroid addiction/withdrawal (TSA/TSW), a systematic review (2015) conducted by the National Eczema Association concluded that RSS/TSA/TSW is a potential adverse effect of prolonged use of topical steroids. The phenomenon of RSS/TSA/TSW has been deemed rare. There is no validated definition, no patient registry, and no evidence-based treatment.
Source: Journal of the American Academy of Dermatology - May 31, 2017 Category: Dermatology Source Type: research

New-onset lupus nephritis after male-to-female sex reassignment surgery.
We report an original case of a 27-year-old transgender woman who developed lupus nephritis after male-to-female sex reassignment surgery. The patient had been taking hormones to induce feminization since the age of 18. She was admitted with malar "butterfly" rash, anasarca and hypertension, associated with an increase in serum creatinine (1.7 mg/dl). Renal involvement was characterized by nephritic and nephrotic syndrome. Autoantibody tests were positive for antinuclear antibodies and anti-double-stranded DNA, and complement levels were markedly reduced. Renal biopsy demonstrated diffuse proliferative glomerulonephritis...
Source: Lupus - September 19, 2018 Category: Rheumatology Authors: Pontes LT, Camilo DT, De Bortoli MR, Santos RSS, Luchi WM Tags: Lupus Source Type: research

IJERPH, Vol. 14, Pages 362: Proximity to Industrial Food Animal Production and Asthma Exacerbations in Pennsylvania, 2005–2012
This study contributes to growing evidence that IFAP may impact health, in this case clinically-documented asthma exacerbations. No prior study has evaluated the association of IFAP and clinically-documented asthma exacerbations in the United State s.
Source: International Journal of Environmental Research and Public Health - March 31, 2017 Category: Environmental Health Authors: Sara Rasmussen Joan Casey Karen Bandeen-Roche Brian Schwartz Tags: Article Source Type: research

SOCS and Herpesviruses, With Emphasis on Cytomegalovirus Retinitis
Christine I. Alston1,2 and Richard D. Dix1,2* 1Department of Biology, Viral Immunology Center, Georgia State University, Atlanta, GA, United States 2Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, United States Suppressor of cytokine signaling (SOCS) proteins provide selective negative feedback to prevent pathogeneses caused by overstimulation of the immune system. Of the eight known SOCS proteins, SOCS1 and SOCS3 are the best studied, and systemic deletion of either gene causes early lethality in mice. Many viruses, including herpesviruses such as herpes simplex virus and cytomega...
Source: Frontiers in Immunology - April 10, 2019 Category: Allergy & Immunology Source Type: research

Bullous pemphigoid after second dose of mRNA- (Pfizer-BioNTech) Covid-19 vaccine: A case report
CONCLUSION: Although uncommon, several dermatological side reactions like bullous eruptions have been reported following the mRNA Pfizer Covid-19 vaccination. According to this case report, Bullous pemphigoid might be caused by the mRNA- (Pfizer) Covid-19 Vaccine.PMID:35251600 | PMC:PMC8885466 | DOI:10.1016/j.amsu.2022.103420
Source: Hand Surgery - March 7, 2022 Category: Surgery Authors: Fouad Alshammari Mohammed Alzomia Abdulrahman Korairi Mohammed Alajlan Yacoub Abuzied Mohammed AlSheef Source Type: research

Systemic corticosteroids for radicular and non-radicular low back pain
CONCLUSIONS: Systemic corticosteroids appear to be slightly effective at improving short-term pain and function in people with radicular low back pain not due to spinal stenosis, and might slightly improve long-term function. The effects of systemic corticosteroids in people with non-radicular low back pain are unclear and systemic corticosteroids are probably ineffective for spinal stenosis. A single dose or short course of systemic corticosteroids for low back pain does not appear to cause serious harms, but evidence is limited.PMID:36269125 | PMC:PMC9585990 | DOI:10.1002/14651858.CD012450.pub2
Source: Cochrane Database of Systematic Reviews - October 21, 2022 Category: General Medicine Authors: Roger Chou Rafael Zambelli Pinto Rongwei Fu Robert A Lowe Nicholas Henschke James H McAuley Tracy Dana Source Type: research

Interventions for preventing and treating kidney disease in IgA vasculitis
CONCLUSIONS: There are no substantial changes in conclusions from this update compared with the initial review or the previous update despite the addition of five studies. From generally low to moderate certainty evidence, we found that there may be little or no benefit in the use of corticosteroids or antiplatelet agents to prevent persistent kidney disease in children with IgAV in participants with no or minimal kidney involvement at presentation. We did not find any studies which evaluated corticosteroids in children presenting with IgAV and nephritic and/or nephrotic syndrome, although corticosteroids are recommended i...
Source: Cochrane Database of Systematic Reviews - February 28, 2023 Category: General Medicine Authors: Deirdre Hahn Elisabeth M Hodson Jonathan C Craig Source Type: research

Inhaled corticosteroids versus placebo   for stable chronic obstructive pulmonary disease
CONCLUSIONS: This systematic review updates the evidence base for ICS monotherapy with newly published trials to aid the ongoing assessment of their role for people with COPD. Use of ICS alone for COPD likely results in a reduction of exacerbation rates of clinical relevance, probably results in a reduction in the rate of decline of FEV1 of uncertain clinical relevance and likely results in a small improvement in health-related quality of life not meeting the threshold for a minimally clinically important difference. These potential benefits should be weighed up against adverse events (likely to increase local oropharyngea...
Source: Cochrane Database of Systematic Reviews - March 27, 2023 Category: General Medicine Authors: Ian A Yang Olivia R Ferry Melissa S Clarke Esther Ha Sim Kwun M Fong Source Type: research